Frontiers in Biomedicine: Prof. Marc Donath

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Jeudi 2 décembre 2021, 12h30 - 13h30
Pr Marc Y. Donath
Division of endocrinology, diabetology & metabolism, University Hospital Basel

«Islet inflammation: physiology, pathology and treatment»

Morphological and therapeutic interventions have uncovered an inflammatory process in patients with type 2 diabetes. This inflammation is due to a pathological activation of the innate immune system by metabolic stress and is largely governed by IL-1 signaling. Initially, the inflammatory response is probably deployed to promote adaptation and regeneration. Indeed, we identified a role for IL-1β and insulin in the regulation of both metabolism and immunity in response to feeding. Yet, as it becomes chronic, activation of auto-inflammatory processes may then become deleterious. It follows that modulation of inflammatory mediators may present as a possible causal therapy. This is supported by clinical studies showing that IL-1 antagonism decreases glycated hemoglobin. Furthermore, IL-1 antagonism prevents heart failure and cardiovascular diseases, the major complication of diabetes.

Auditoire Alex-F. Müller (A250)
Dernière mise à jour : 29/11/2021