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English summary: Xenotransplantation and ABO-Incompatibility
The current organ shortage in transplantation medicine stimulates the exploration of new strategies to expand the donor pool including the utilization of living donors, ABO-incompatible grafts and xenotransplantation. Preformed natural antibodies (NAb) such as anti-A/B histoblood group isoagglutinins and xenoreactive anti-Galα1,3Gal antibodies mediate humoral graft rejection whereas delayed xenograft rejection (DXR) in xenotransplanatation is characterized by graft infiltration with innate immune cells. Monocytes and polymorphonuclear neutrophils (PMN) are among the earliest recruited to xenografts and NK cells play a much more significant role in the rejection of xenografts than allografts. Our research projects focus on the following goals: