Well established risk factors, including smoking or obesity, have been shown to increase risk for adverse outcomes such as cardiovascular events or mortality. Yet, among certain subgroups of people, the risk of disease sequelae has sometimes been paradoxical. For example, smokers have been shown to have lower mortality after acute coronary syndrome than nonsmokers (smoking paradox) or overweight or obese people were at lower risk for mortality than normal weight (obesity paradox). We will discuss several possible methodologic issues that may explain this paradoxical phenomenon, using examples from the rheumatic disease research.
Uyen-Sa Nguyen (DSc, MPH, Assistant Professor, Boston University School of Medicine)
Salon d'accueil - salle 7A-8-739 – 8ème étage - Cluse Roseraie