Unité de neuroimmunologie et des maladies neuromusculaires

1- NEUROIMMUNOLOGIE

Pr Patrice Lalive d’Epinay
Médecin adjoint agrégé, responsable de l’unité de neuroimmunologie et des maladies neuromusculaires

L’unité mène ou participe aux projets de recherche suivants :

Recherche fondamentale

Domaines de recherche : neuroimmunologie, sclérose en plaques, biomarqueurs, encéphalite autoimmune expérimentale (EAE)

  • Sclérose en plaques (SEP) et maladies démyélinisantes du système nerveux central (SNC)
  • Etude et validation de biomarqueurs du LCR dans les maladies inflammatoires du SNC
  • Encéphalite autoimmune expérimentale (EAE)
  • Evaluation du « hepatocyte growth factor » comme immunomodulateur et neuroprotecteur dans l’EAE (projet FNS)
  • Etude des mécanismes d’actions des immunomodulateurs/-suppresseurs dans la SEP

Recherche clinique

  • Swiss MS cohort
    Responsable de l’antenne genevoise de la cohorte suisse de SEP (collaboration DIAGNO/Sérothèque/CRC).
    Projet Suisse multicentrique
  • Etude mobilité et cognition dans la SEP  (co-investigateurs: Patrice Lalive, Gilles Allali) 
    Etude prospective visant à identifier des marqueurs de handicaps moteurs et cognitifs dans la sclérose en plaques 

 

Pour en savoir plus, consultez :

Consultez aussi les activités médicales de l'unité de neuroimmunologie et des maladies neuromusculaires

 

2- MALADIES NEUROMUSCULAIRES

PD Dre Annemarie Hübers, Médecin adjointe agrégée, Service de neurologie: Annemarie.Hubers@hcuge.ch 

Publications

2020

  • Hübers A, Lascano AM, Lalive PH. Management of patients with generalised myasthenia gravis and COVID-19: four case reports. J Neurol Neurosurg Psychiatry 2020; 91:1124-1125.
  • Coen M, Jeanson G, Culebras Almeida LA, Hübers A, Stierlin F, Najjar I, Ongaro M, Moulin K, Makrygianni M, Leemann B, Kronig I, Bertrand J, Reny JL, Schibler M, Serratrice J. Guillain-Barré syndrome as a complication of SARS- CoV-2 infection. Brain Behav Immun. 2020 Jul;87:111-112.
  • Sukockiené E, Magistris MR, Iancu Ferfoglia R, Lascano AM, Truffert A. Impaired conduction of Ia sensory fibers in multifocal motor neuropathy: an electrophysiological demonstration. Clin Neurophysiol Pract 2020; 5:152-156.
  • Hübers A, Böckler B, Abaei A, Rasche V, Lulé D, Ercan E, Doorenweerd N, Müller HP, Dreyhaupt J, Kammer T, Ludolph AC, Ronen I, Kassubek J. Functional and structural impairment of transcallosal motor fibres in ALS: a study using transcranial magnetic stimulation, diffusion tensor imaging, and diffusion weighted spectroscopy. Brain Imaging Behav. 2020 Apr 18. 
  • Lascano AM, Epiney JB, Coen M, Serratrice J, Bernard-Valnet R, Lalive PH, Kuntzer T, Hübers A. SARS-CoV-2 and Guillain-Barré syndrome: AIDP variant with favorable outcome. EJN 2020 (Epub).
  • Huttner A, Eperon G, Lascano AM, Roth S, Schwob JM, Siegrist CA, Lalive PH. Risk of MS relapse after yellow fever vaccination: a self-controlled case series. Neurol Neuroimmunol Neuroinflamm 2020; 7:e726.
  • Jannelli G, Baticam NS, Tizi K, Truffert A, Lascano AM, Tessitore E. Symptomatic tandem spinal stenosis: a clinical, diagnostic and surgical challenge. Neurosurg Rev 2020; 43:1289-1295.
  • Huttner A, Lascano AM, Eperon G, Roth S, Schwob JM, Siegrist CA, Lalive PH. The risk of multiple sclerosis relapse after rabies vaccination: a self-controlled case series (Soumis et en révision).
  • Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH; Delegates of the 2nd International PLS Conference, Mitsumoto H. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):373-377. 

2019

  • Tazelaar GHP, Dekker AM, van Vugt JJFA, van der Spek RA, Westeneng HJ, Kool LJBG, Kenna KP, van Rheenen W, Pulit SL, McLaughlin RL, Sproviero W, Iacoangeli A, Hübers A, Brenner D, Morrison KE, Shaw PJ, Shaw CE, Panadés MP, Mora Pardina JS, Glass JD, Hardiman O, Al-Chalabi A, van Damme P, Robberecht W, Landers JE, Ludolph AC, Weishaupt JH, van den Berg LH, Veldink JH, van Es MA; Project MinE ALS Sequencing Consortium. Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort. Neurobiol Aging. 2019 Feb;74:234.e9-234.
  • Breville G, Lascano AM, Roux-Lombard P, Vuilleumier N, Lalive P. IL-8 as a potential biomarker in Guillain-Barre syndrome. Eur Cytokine Netw 2019 ; 30 :130-134.
  • Naumann M, Peikert K, Günther R, van der Kooi AJ, Aronica E, Hübers A, Danel V, Corcia P, Pan-Montojo F, Cirak S, Haliloglu G, Ludolph AC, Goswami A, Andersen PM, Prudlo J, Wegner F, Van Damme P, Weishaupt JH, Hermann A. Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2019 Dec;6(12):2384-2394.
  • Breville G, Lascano AM, Merkler D, Roth S, Lalive PH. Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient. Mult Scler Relat Disord 2019 (Epub).
  • Brenner D, Rosenbohm A, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET. Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations. Brain. 2019 Dec 1;142(12):e67. 
  • De Stefano P, Lascano AM, Schibler M, Fistori A, Lalive P, Gschwind M. Pachymeningitis associated to extrapulmonary tuberculosis and secondary antiphospholipid antibodies syndrome. Mult Scler Relat Disord 2019; 29:83-85.
  • Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, Rosenbohm A, Sijlmans C, Aly A, Mersmann S, Sanjuan-Ruiz I, Hübers A, Messaddeq N, Wagner M, van Bakel N, Boutillier AL, Ludolph A, Lagier-Tourenne C, Boeckers TM, Dupuis L, Storkebaum E. FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis. Nat Neurosci. 2019 Nov;22(11):1793-1805.
  • Lamartine Monteiro M, Lascano AM, Meunier Carus Vincent N, Seebach JD, Lalive P, Gschwind M. AQP4-positive longitudinal extensive transverse myelitis associated with Takayasu arteritis. J Neurol Sci 2019; 396:130-132.
  • Dorst J, Chen L, Rosenbohm A, Dreyhaupt J, Hübers A, Schuster J, Weishaupt JH, Kassubek J, Gess B, Meyer T, Weyen U, Hermann A, Winkler J, Grehl T, Hagenacker T, Lingor P, Koch JC, Sperfeld A, Petri S, Großkreutz J, Metelmann M, Wolf J, Winkler AS, Klopstock T, Boentert M, Johannesen S, Storch A, Schrank B, Zeller D, Liu XL, Tang L, Fan DS, Ludolph AC. Prognostic factors in ALS: a comparison between Germany and China. J Neurol. 2019 Jun;266(6):1516-1525. 
  • Schibler M, Eperon G, Kenfak A, Lascano A, Vargas MI, Stahl JP. Diagnostic tool to tackle infectious causes of encephalitis and meningoencephalitis in immunocompetent adults in Europe. Clin Microbiol Infect 2019; 25:408-414.
  • Lascano AM, Vargas MI, Lalive P. Diagnostic tools for immune causes of encephalitis. Clin Microbiol Infect 2019; 25:431-436.
  • Hübers A, Huppertz HJ, Wortmann SB, Kassubek J. Mutation of the <i>WARS2</i> Gene as the Cause of a Severe Hyperkinetic Movement Disorder. Mov Disord Clin Pract. 2019 Nov 7;7(1):88-90. 

2018

  • Müller K, Brenner D, Weydt P, Meyer T, Grehl T, Petri S, Grosskreutz J, Schuster J, Volk AE, Borck G, Kubisch C, Klopstock T, Zeller D, Jablonka S, Sendtner M, Klebe S, Knehr A, Günther K, Weis J, Claeys KG, Schrank B, Sperfeld AD, Hübers A, Otto M, Dorst J, Meitinger T, Strom TM, Andersen PM, Ludolph AC, Weishaupt JH; German ALS network MND-NET. Comprehensive analysis of the mutation spectrum in 301 German ALS families. J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):817-827. 
  • De Stefano P, Chizzolini C, Lalive PH, Lascano AM. Limbic encephalitis complicating systemic sclerosis. Mult. Scler Rel. Disord. 2018; 24: 142-144.
  • Marroquin N, Stranz S, Müller K, Wieland T, Ruf WP, Brockmann SJ, Danzer KM, Borck G, Hübers A, Weydt P, Meitinger T, Strom TM, Rosenbohm A, Ludolph AC, Weishaupt JH. Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant. Brain. 2016 Feb;139(Pt 2):e8. 
  • Abdelhak A, Hübers A, Böhm K, Ludolph AC, Kassubek J, Pinkhardt EH. In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis. J Neurol. 2018 Apr;265(4):949-953. doi: 10.1007/s00415-018-8787-x. Epub 2018 Feb 20. 
  • Hübers A, Thoma K, Schocke M, Fauser S, Ludolph AC, Kassubek J, Pinkhardt EH. Acute DWI Reductions In Patients After Single Epileptic Seizures – More Common Than Assumed. Front Neurol. 2018 Jul 25;9:550. 
  • Brenner D, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Strom TM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET. Hot-spot KIF5A mutations cause familial ALS. Brain. 2018 Mar 1;141(3):688-697.
  • Gschwind M, Lascano AM, Gürkan K, Assal F. Self-injurious behavior unveiling a case of advanced primary progressive multiple sclerosis with a massive right temporal lesion. J Clin Neurol 2018; 14: 251-253.
  • Neuwirth C, Braun N, Claeys KG, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Appelfeller M, Tümmler A, Finegan E, Glass JD, Babu S, Ladha SS, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, Weber M. Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres. Clin Neurophysiol. 2018 Aug;129(8):1756-1762. 

2017

  • Dorst J, Ludolph AC, Hubers A. Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis. Ther Adv Neurol Disord. 2017 Oct 9;11: 1756285617734734.
  • Moreno Legast G. Lascano AM, Gschwind M, Schnider A, Nicastro N. Guillain Barré and Miller Fisher overlap syndrome mimicking alimentary botulism. J Clin Neurol 2017; 13: 442-443.
  • Nordin A, Akimoto C, Wuolikainen A, Alstermark H, Forsberg K, Baumann P, Pinto S, de Carvalho M, Hübers A, Nordin F, Ludolph AC, Weishaupt JH, Meyer T, Grehl T, Schweikert K, Weber M, Burkhardt C, Neuwirth C, Holmøy T, Morita M, Tysnes OB, Benatar M, Wuu J, Lange DJ, Bisgård C, Asgari N, Tarvainen I, Brännström T, Andersen PM. Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study. Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):256-264. 
  • Lascano AM, Lalive PH, Hardmeier M, Fuhr P, Seeck M. Clinical evoked potentials in neurology: a review of techniques and indications. J Neurol Neurosurg Psychiatry 2017; 88: 688-696.
  • Hubers AJ, Heideman DA, Duin S, Witte BI, de Koning HJ, Groen HJ, Prinsen CF, Bolijn AS, Wouters M, van der Meer SE, Steenbergen RD, Snijders PJ, Uyterlinde A, Berkhof H, Smit EF, Thunnissen E. DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2 years. J Clin Pathol.2017 Mar;70(3):250-254. 

2016

  • Higelin J, Demestre M, Putz S, Delling JP, Jacob C, Lutz AK, Bausinger J, Huber AK, Klingenstein M, Barbi G, Speit G, Hubers A, Weishaupt JH, Hermann A, Liebau S, Ludolph AC, Boeckers TM. FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons. Front Cell Neurosci. 2016 Dec 26;10:290.
  • Fisch L, Lascano AM, Vernaz Hegi N, Girardin F, Kapina V, Heydrich L, Rutschmann O, Sarasin F, Vargas MI, Picard F, Vulliemoz S, Heritier AC, Seeck M. Early-specialized care after a first unprovoked epileptic seizure. J Neurol 2016; 263: 2386-2394.
  • Rosenbohm A, Müller HP, Hübers A, Ludolph AC, Kassubek J. Corticoefferent pathways in pure lower motor neuron disease: a diffusion tensor imaging study. J Neurol. 2016 Dec;263(12):2430-2437. 
  • Hübers A, Hildebrandt V, Petri S, Kollewe K, Hermann A, Storch A, Hanisch F, Zierz S, Rosenbohm A, Ludolph AC, Dorst J. Clinical features and differential diagnosis of flail arm syndrome. J Neurol. 2016 Feb;263(2):390-395.
  • Tyrand R, Momjian S, Pollo C, Lysakowski C, Lascano AM, Vulliemoz S, Schaller K, Boex C. Continuous intraoperative monitoring of temporal lobe epilepsy surgery. Stereotac Funct Neurosurg 2016; 94: 404-412.
  • Hübers A, Ludolph AC, Rosenbohm A, Pinkhardt EH, Weishaupt JH, Dorst J. Amyotrophe Lateralsklerose. Eine Multisystemdegeneration [Amyotrophic lateral sclerosis. Multisystem degeneration]. Nervenarzt. 2016 Feb;87(2):179-88. 
  • Lascano AM, Pernegger T, Vulliemoz S, Spinelli L, Garibotto V, C. Korff, Vargas MI, Michel CM, Seeck M. Yield of MRI, high-density source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates. Clin Neurophysiology 2016; 127: 5-7. 
  • Hübers A, Müller HP, Dreyhaupt J, Böhm K, Lauda F, Tumani H, Kassubek J, Ludolph AC, Pinkhardt EH. Retinal involvement in amyotrophic lateral sclerosis: a study with optical coherence tomography and diffusion tensor imaging. J Neural Transm (Vienna). 2016 Mar;123(3):281-7. 
  • Lascano AM, Korff C, Picard F. Seizures and epilepsies due to channelopathies and neurotransmitter receptor dysfunction: a parallel between genetic and immune aspects. Mol Syndromol 2016; 7:197-209.
  • Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 May;139(Pt 5):e28.
  • Hübers A, Kassubek J, Grön G, Gorges M, Aho-Oezhan H, Keller J, Horn H, Neugebauer H, Uttner I, Lulé D, Ludolph AC. Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function. J Neurol. 2016 Sep;263(9):1788-95. 
  • Wahl M, Lauterbach-Soon B, Hattingen E, Hübers A, Ziemann U. Callosal anatomical and effective connectivity between primary motor cortices predicts visually cued bimanual temporal coordination performance. Brain Struct Funct. 2016 Sep;221(7):3427-43.
  • Rennebaum F, Kassubek J, Pinkhardt E, Hübers A, Ludolph AC, Schocke M, Fauser S. Status epilepticus: Clinical characteristics and EEG patterns associated with and without MRI diffusion restriction in 69 patients. Epilepsy Res. 2016 Feb;120:55-64. 

 

Dernière mise à jour : 27/11/2020