Recherche

Partager Imprimer
Adresse

Rue Gabrielle-Perret-Gentil 4
1205 Genève
Suisse

Pre
Isabella Eckerle
Médecin responsable du Centre
Pr
Laurent Kaiser
Chef de service
Docteur
Pascal Cherpillod
Biologiste responsable du CRIVE
Docteur
Pauline Vetter
Médecin du Centre
Groupes de recherche:

Le groupe "Virus émergents" est dirigé par le Pr Isabella Eckerle, membre du "High-level European expert group proposing a roadmap towards stabilization of the COVID-19 pandemic in the European region".

Ce groupe est le groupe de recherche affilié au Centre de Genève pour les maladies virales émergentes, une institution conjointe entre les Hôpitaux universitaires de Genève (HUG) et la Faculté de médecine de l'Université de Genève, le laboratoire principal du groupe de recherche étant situé au Département de microbiologie et de médecine moléculaire (MIMOL) du Centre médical universitaire (CMU).

Nos recherches se concentrent sur l'évaluation en laboratoire du risque de virus zoonotiques nouveaux et émergents par des méthodes moléculaires et virologiques classiques, en utilisant des modèles de culture cellulaire innovants et hautement spécifiques provenant de l'homme et d'hôtes réservoirs animaux. Depuis le début de la pandémie de SRAS-CoV-2, notre laboratoire est fortement impliqué dans le développement et la validation de diagnostics pour le SRAS-CoV-2, ainsi que dans des projets de recherche sur le SRAS-CoV-2, par exemple sur l'excrétion virale, les études d'isolement du virus, la création d'une biobanque SRAS-CoV-2, la caractérisation moléculaire et phénotypique et la coinfection avec d'autres virus respiratoires dans des cellules épithéliales primaires des voies respiratoires et des études cliniques et immunologiques.

Le groupe de recherche est étroitement lié au laboratoire de diagnostic virologique et au Centre de référence des infections virales émergentes (CRIVE) des HUG. Le Centre abrite les seules installations P3 et P4D du canton de Genève, situées aux HUG, où sont réalisés nos travaux sur le SRAS-CoV-2 infectieux.

Lien vers le site Web du groupe du Pr Isabella Eckerle à la Faculté de Médecine de Genève: https://www.unige.ch/medecine/demed/en/groupes-de-recherche/isabella-eckerle

Ce laboratoire est l'un des 26 laboratoires de référence internationaux pour le test COVID19 désignés par l'Organisation mondiale de la santé, auxquels notre groupe contribue en termes de validations du diagnostic du SRAS-CoV-2 (Réseau de laboratoires de référence COVID-19 de l'OMS).

https://www.who.int/docs/default-source/coronaviruse/who-reference-laboratories-providing-confirmatory-testing-for-covid-19.pdf?sfvrsn=a03a01e6_2

Le laboratoire est également un partenaire collaborateur de la Foundation of Innovative Diagnostics (FIND) afin de fournir un soutien pour des diagnostics précis du SRAS-CoV-2. Les mises à jour des validations actuelles des tests moléculaires et des tests de diagnostic rapide à détection d'antigène sont disponibles ici :

https://www.finddx.org/covid-19/sarscov2-eval/

Des collaborations étroites existent également avec le Service des maladies infectieuses, l'Unité d'épidémiologie des populations, l'Unité des maladies infectieuses pédiatriques des HUG et le Centre de vaccinologie du Département de pathologie et d'immunologie de l'Unige.

Fonds de recherche :

- Horizon 2020, Union européenne, Projet : " European Clinical Research Alliance on Infectious Diseases - ECRAID-Base ".

Swiss National Foundation (SNF) National Research Program (NRP) 78 "Covid-19", Projet: "Profilage sérologique à grande échelle du SRAS-CoV-2 et des CoVs humains apparentés à l'aide de nano-immuno-essais microfluidiques à haut débit",

Co-application avec Sebastian Maerkl, École polytechnique fédérale de Lausanne (EPFL)

- Swiss National Foundation (SNF), Special call on coronaviruses, Projet : " Caractérisation phénotypique d'une biobanque de souches cliniques de SRAS-CoV-2 et évaluation du risque d'évolution des variants du virus ",

- Swiss National Foundation (SNF), Special call on coronaviruses, Projet : "Caractérisation fonctionnelle pandémique en temps réel du SARS-CoV-2".

Co-application avec Volker Thiel et Ronald Dijkman (Institut de Virologie et d'Immunologie, Berne)

- Laboratoire collaborateur pour la Foundation for Innovative Diagnostics (FIND) : "Soutien au diagnostic précis du 2019-nCoV".

 

Fondation privée HUG : Soutien à la réponse rapide pour le SRAS-CoV-2

Fondation Pictet, Projet : "COVID-19, le nouveau défi du Centre de maladies virales émergentes - Comprendre la transmission et les facteurs de risque du COVID-19 dans des modèles de culture cellulaire primaire".

Fondation Ernst et Lucie Schmidheiny, Projet : "Évaluation de la capacité de changement d'hôte des filovirus de chauve-souris nouvellement identifiés par le biais d'un changement d'un seul acide aminé dans la glycoprotéine du pic".

 

Isabella Eckerle fait également partie des initiatives suivantes:

- Commission ad hoc sur le SARS-CoV-2 de la Société de Virologie (virologistes germanophones, Allemagne, Suisse, Autriche, "Gesellschaft für Virologie")

https://www.g-f-v.org/stellungnahmen

- Commission COVID-19 de The Lancet : Taskforce on the Origins, Early Control of the Pandemic, and One Health Solutions to Future Pandemic Threats (Groupe de travail sur les origines, le contrôle précoce de la pandémie et les solutions " One Health " aux futures menaces de pandémie)

https://covid19commission.org/origins-of-the-pandemic

- Co-auteur et co-initiateur du mémorandum de John Snow

Alwan NA, Burgess RA, Ashworth S, Beale R, Bhadelia N, Bogaert D, Dowd J, Eckerle I, Goldman LR, Greenhalgh T, Gurdasani D, Hamdy A, Hanage WP, Hodcroft EB, Hyde Z, Kellam P, Kelly-Irving M, Krammer F, Lipsitch M, McNally A, McKee M, Nouri A, Pimenta D, Priesemann V, Rutter H, Silver J, Sridhar D, Swanton C, Walensky RP, Yamey G, Ziauddeen H. Consensus scientifique sur la pandémie de COVID-19 : nous devons agir maintenant.

Lancet. 2020 Oct 15

- Expert invité à l'Organisation mondiale de la santé (OMS), Forum mondial de la recherche et de l'innovation : vers une feuille de route de la recherche sur le nouveau coronavirus de 2019, initiative R&D Blueprint (11-12 février 2020).

Membre du groupe d'experts sur l'histoire naturelle et la transmission du virus.

- Organisation mondiale de la santé (OMS), Groupe de profils de produits cibles : COVID-19 Target product profiles for priority diagnostics to support response to the COVID-19 pandemic v.1.0, 29 septembre 2020, https://www.who.int/publications/m/item/covid-19-target-product-profiles-for-priority-diagnostics-to-support-response-to-the-covid-19-pandemic-v.0.1 (en anglais)

- Organisation mondiale de la santé (OMS): Conseiller temporaire auprès de l'OMS pour la consultation d'experts sur la transmission mère-enfant du coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2) (octobre 2020).

Publications:

Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland.
Chen C, Nadeau SA, Topolsky I, Manceau M, Huisman JS, Jablonski KP, Fuhrmann L, Dreifuss D, Jahn K, Beckmann C, Redondo M, Noppen C, Risch L, Risch M, Wohlwend N, Kas S, Bodmer T, Roloff T, Stange M, Egli A, Eckerle I, Kaiser L, Denes R, Feldkamp M, Nissen I, Santacroce N, Burcklen E, Aquino C, de Gouvea AC, Moccia MD, Grüter S, Sykes T, Opitz L, White G, Neff L, Popovic D, Patrignani A, Tracy J, Schlapbach R, Dermitzakis ET, Harshman K, Xenarios I, Pegeot H, Cerutti L, Penet D, Blin A, Elies M, Althaus CL, Beisel C, Beerenwinkel N, Ackermann M, Stadler T.Epidemics. 2021 Aug 9;37:100480. doi: 10.1016/j.epidem.2021.100480. Online ahead of print.PMID: 34488035

Estimating clinical SARS-CoV-2 infectiousness in Vero E6 and primary airway epithelial cells.
Essaidi-Laziosi M, Perez Rodriguez FJ, Hulo N, Jacquerioz F, Kaiser L, Eckerle I. Lancet Microbe. 2021 Aug 27. doi: 10.1016/S2666-5247(21)00216-0. Online ahead of print.PMID: 34485956  

Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains.
Binder F, Gallo G, Bendl E, Eckerle I, Ermonval M, Luttermann C, Ulrich RG.Arch Virol. 2021 Aug 13:1-14. doi: 10.1007/s00705-021-05159-y. Online ahead of print.PMID: 34389893 

SARS-CoV-2 infection as a trigger of humoral response against apolipoprotein A-1.
Pagano S, Yerly S, Meyer B, Juillard C, Suh N, Le Terrier C, Daguer JP, Farrera-Soler L, Barluenga S, Piumatti G, Hartley O, Lemaitre B, Eberhardt CS, Siegrist CA, Eckerle I, Stringhini S, Guessous I, Kaiser L, Pugin J, Winssinger N, Vuilleumier N.Eur J Clin Invest. 2021 Jul 29:e13661. doi: 10.1111/eci.13661. Online ahead of print.PMID: 34324704

Persistence of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance.
Perez-Saez J, Zaballa ME, Yerly S, Andrey DO, Meyer B, Eckerle I, Balavoine JF, Chappuis F, Pittet D, Trono D, Kherad O, Vuilleumier N, Kaiser L, Guessous I, Stringhini S, Azman AS; Specchio-COVID19 Study Group.Clin Microbiol Infect. 2021 Jul 7:S1198-743X(21)00371-2. doi: 10.1016/j.cmi.2021.06.040. Online ahead of print.PMID: 34245905 

SARS-CoV-2 rapid diagnostic tests for emerging variants.
Bekliz M, Adea K, Essaidi-Laziosi M, Sacks JA, Escadafal C, Kaiser L, Eckerle I.Lancet Microbe. 2021 Aug;2(8):e351. doi: 10.1016/S2666-5247(21)00147-6. Epub 2021 Jun 29.PMID: 34223400 

Diagnostic Accuracy of SARS-CoV-2 Rapid Antigen Detection Testing in Symptomatic and Asymptomatic Children in the Clinical Setting.
L'Huillier AG, Lacour M, Sadiku D, Gadiri MA, De Siebenthal L, Schibler M, Eckerle I, Pinösch S, Kaiser L, Gervaix A, Glangetas A, Galetto-Lacour A, Lacroix L.J Clin Microbiol. 2021 Aug 18;59(9):e0099121. doi: 10.1128/JCM.00991-21. Epub 2021 Aug 18.PMID: 34190574 

Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2.
Ngo Nsoga MT, Kronig I, Perez Rodriguez FJ, Sattonnet-Roche P, Da Silva D, Helbling J, Sacks JA, de Vos M, Boehm E, Gayet-Ageron A, Berger A, Jacquerioz-Bausch F, Chappuis F, Kaiser L, Schibler M, Renzoni A, Eckerle I.PLoS One. 2021 Jun 24;16(6):e0253321. doi: 10.1371/journal.pone.0253321. eCollection 2021.PMID: 34166410 

Sero-molecular epidemiology of hepatitis E virus in pigs and human contacts in Ghana.
Yeboah R, Sylverken AA, Owusu M, El-Duah P, Burimuah V, Frimpong Y, Lamptey J, Eckerle I, Meyer B, Antwi C, Agbenyaga O, Folitse R, Emikpe B, Oppong SK, Adu-Sarkodie Y, Drosten C.One Health Outlook. 2021 Jun 22;3(1):13. doi: 10.1186/s42522-021-00043-w.PMID: 34154674 

Insights into household transmission of SARS-CoV-2 from a population-based serological survey.
Bi Q, Lessler J, Eckerle I, Lauer SA, Kaiser L, Vuilleumier N, Cummings DAT, Flahault A, Petrovic D, Guessous I, Stringhini S, Azman AS; SEROCoV-POP Study Group.Nat Commun. 2021 Jun 15;12(1):3643. doi: 10.1038/s41467-021-23733-5.PMID: 34131124 

Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland.
Stringhini S, Zaballa ME, Pullen N, de Mestral C, Perez-Saez J, Dumont R, Picazio A, Pennacchio F, Dibner Y, Yerly S, Baysson H, Vuilleumier N, Balavoine JF, Bachmann D, Trono D, Pittet D, Chappuis F, Kherad O, Kaiser L, Azman AS; SEROCoV-WORK + Study Group, Guessous I.Nat Commun. 2021 Jun 8;12(1):3455. doi: 10.1038/s41467-021-23796-4.PMID: 34103517 

Novel SARS-CoV-2 variants: the pandemics within the pandemic.
Boehm E, Kronig I, Neher RA, Eckerle I, Vetter P, Kaiser L; Geneva Centre for Emerging Viral Diseases.Clin Microbiol Infect. 2021 Aug;27(8):1109-1117. doi: 10.1016/j.cmi.2021.05.022. Epub 2021 May 17.PMID: 34015535 

Case Report: Stepwise Anti-Inflammatory and Anti-SARS-CoV-2 Effects Following Convalescent Plasma Therapy With Full Clinical Recovery.
Zimmerli A, Monti M, Fenwick C, Eckerle I, Beigelman-Aubry C, Pellaton C, Jaton K, Dumas D, Stamm GM, Infanti L, Andreu-Ullrich H, Germann D, Mean M, Vollenweider P, Stadelmann R, Prella M, Comte D, Guery B, Gachoud D, Rufer N.Front Immunol. 2021 Apr 21;12:613502. doi: 10.3389/fimmu.2021.613502. eCollection 2021.PMID: 33968017 

SARS-CoV-2 viral load kinetics in symptomatic children, adolescents and adults.
Bellon M, Baggio S, Bausch FJ, Spechbach H, Salamun J, Genecand C, Tardin A, Kaiser L, L'Huillier AG, Eckerle I.Clin Infect Dis. 2021 May 5:ciab396. doi: 10.1093/cid/ciab396. Online ahead of print.PMID: 33949655 

A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples.
Swank Z, Michielin G, Yip HM, Cohen P, Andrey DO, Vuilleumier N, Kaiser L, Eckerle I, Meyer B, Maerkl SJ.Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2025289118. doi: 10.1073/pnas.2025289118.PMID: 33945500 

Head-to-Head Evaluation of Five Automated SARS-CoV-2 Serology Immunoassays in Various Prevalence Settings.
Andrey DO, Yerly S, Meyer B, Arm-Vernez I, Roux-Lombard P, Togni G, Guessous I, Spechbach H, Stringhini S, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N.J Clin Med. 2021 Apr 10;10(8):1605. doi: 10.3390/jcm10081605.PMID: 33920076 

SARS-CoV-2 N501Y Introductions and Transmissions in Switzerland from Beginning of October 2020 to February 2021-Implementation of Swiss-Wide Diagnostic Screening and Whole Genome Sequencing.
Goncalves Cabecinhas AR, Roloff T, Stange M, Bertelli C, Huber M, Ramette A, Chen C, Nadeau S, Gerth Y, Yerly S, Opota O, Pillonel T, Schuster T, Metzger CMJA, Sieber J, Bel M, Wohlwend N, Baumann C, Koch MC, Bittel P, Leuzinger K, Brunner M, Suter-Riniker F, Berlinger L, Søgaard KK, Beckmann C, Noppen C, Redondo M, Steffen I, Seth-Smith HMB, Mari A, Lienhard R, Risch M, Nolte O, Eckerle I, Martinetti Lucchini G, Hodcroft EB, Neher RA, Stadler T, Hirsch HH, Leib SL, Risch L, Kaiser L, Trkola A, Greub G, Egli A.Microorganisms. 2021 Mar 25;9(4):677. doi: 10.3390/microorganisms9040677.PMID: 33806013 

Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers.
Berger A, Nsoga MTN, Perez-Rodriguez FJ, Aad YA, Sattonnet-Roche P, Gayet-Ageron A, Jaksic C, Torriani G, Boehm E, Kronig I, Sacks JA, de Vos M, Bausch FJ, Chappuis F, Renzoni A, Kaiser L, Schibler M, Eckerle I.PLoS One. 2021 Mar 31;16(3):e0248921. doi: 10.1371/journal.pone.0248921. eCollection 2021.PMID: 33788882 

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroconversion and occupational exposure of employees at a Swiss university hospital: A large longitudinal cohort study.
Martischang R, Iten A, Arm I, Abbas M, Meyer B, Yerly S, Eckerle I, Pralong J, Sauser J, Suard JC, Kaiser L, Pittet D, Harbarth S.Infect Control Hosp Epidemiol. 2021 Mar 19:1-8. doi: 10.1017/ice.2021.117. Online ahead of print.PMID: 33736734 

Molecular epidemiology of respiratory syncytial virus in children in sub-Saharan Africa.
Ihling CM, Schnitzler P, Heinrich N, Mangu C, Sudi L, Souares A, Gies S, Sié A, Coulibaly B, Ouédraogo AT, Mordmüller B, Held J, Adegnika AA, Fernandes JF, Eckerle I, May J, Hogan B, Eibach D, Tabatabai J.Trop Med Int Health. 2021 Jul;26(7):810-822. doi: 10.1111/tmi.13573. Epub 2021 Mar 28.PMID: 33683751

Clinical, virologic and immunologic features of a mild case of SARS-CoV-2 reinfection.
Vetter P, Cordey S, Schibler M, Vieux L, Despres L, Laubscher F, Andrey DO, Martischang R, Harbarth S, Cuvelier C, Bekliz M, Eckerle I, Siegrist CA, Didierlaurent AM, Eberhardt CS, Meyer B, Kaiser L; Geneva Center for Emerging Viral Diseases.Clin Microbiol Infect. 2021 Feb 20;27(5):791.e1-4. doi: 10.1016/j.cmi.2021.02.010. Online ahead of print.PMID: 33618012 

Viral Loads of SARS-CoV-2 in Young Children.
L'Huillier AG, Baggio S, Eckerle I.JAMA Pediatr. 2021 May 1;175(5):529-530. doi: 10.1001/jamapediatrics.2020.5548.PMID: 33523127 

Viral co-infections among SARS-CoV-2-infected children and infected adult household contacts.
Pigny F, Wagner N, Rohr M, Mamin A, Cherpillod P, Posfay-Barbe KM, Kaiser L, Eckerle I, L'Huillier AG; Geneva Pediatric COVID Group.Eur J Pediatr. 2021 Jun;180(6):1991-1995. doi: 10.1007/s00431-021-03947-x. Epub 2021 Jan 27.PMID: 33502627 

Puumala Virus Infection in Family, Switzerland.
Vetter P, L'Huillier AG, Montalbano MF, Pigny F, Eckerle I, Torriani G, Rothenberger S, Laubscher F, Cordey S, Kaiser L, Schibler M.Emerg Infect Dis. 2021 Feb;27(2):658-660. doi: 10.3201/eid2702.203770.PMID: 33496646 

An action plan for pan-European defence against new SARS-CoV-2 variants.
Priesemann V, Balling R, Brinkmann MM, Ciesek S, Czypionka T, Eckerle I, Giordano G, Hanson C, Hel Z, Hotulainen P, Klimek P, Nassehi A, Peichl A, Perc M, Petelos E, Prainsack B, Szczurek E.Lancet. 2021 Feb 6;397(10273):469-470. doi: 10.1016/S0140-6736(21)00150-1. Epub 2021 Jan 21.PMID: 33485462 

Antibody persistence in the first 6 months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study.
L'Huillier AG, Meyer B, Andrey DO, Arm-Vernez I, Baggio S, Didierlaurent A, Eberhardt CS, Eckerle I, Grasset-Salomon C, Huttner A, Posfay-Barbe KM, Royo IS, Pralong JA, Vuilleumier N, Yerly S, Siegrist CA, Kaiser L; Geneva Centre for Emerging Viral Diseases.Clin Microbiol Infect. 2021 Jan 20;27(5):784.e1-8. doi: 10.1016/j.cmi.2021.01.005. Online ahead of print.PMID: 33482352 

Precision global health for real-time action.
Flahault A, Utzinger J, Eckerle I, Sheath DJ, de Castañeda RR, Bolon I, Bempong NE, Andayi F.Lancet Digit Health. 2020 Feb;2(2):e58-e59. doi: 10.1016/S2589-7500(19)30240-7. Epub 2020 Jan 27.PMID: 33334561 Review. 

Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity.
Yahav D, Yelin D, Eckerle I, Eberhardt CS, Wang J, Cao B, Kaiser L.Clin Microbiol Infect. 2021 Mar;27(3):315-318. doi: 10.1016/j.cmi.2020.11.028. Epub 2020 Dec 5.PMID: 33285276 

Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019.
Grazioli S, Tavaglione F, Torriani G, Wagner N, Rohr M, L'Huillier AG, Leclercq C, Perrin A, Bordessoule A, Beghetti M, Schmid JP, Vavassori S, Perreau M, Eberhardt C, Didierlaurent A, Kaiser L, Eckerle I, Roux-Lombard P, Blanchard-Rohner G.J Pediatric Infect Dis Soc. 2021 Aug 14;10(6):706-713. doi: 10.1093/jpids/piaa142.PMID: 33180935 

Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series.
Vetter P, Eberhardt CS, Meyer B, Martinez Murillo PA, Torriani G, Pigny F, Lemeille S, Cordey S, Laubscher F, Vu DL, Calame A, Schibler M, Jacquerioz F, Blanchard-Rohner G, Siegrist CA, Kaiser L, Didierlaurent AM, Eckerle I.mSphere. 2020 Nov 11;5(6):e00827-20. doi: 10.1128/mSphere.00827-20.PMID: 33177214 

Scientific consensus on the COVID-19 pandemic: we need to act now.
Alwan NA, Burgess RA, Ashworth S, Beale R, Bhadelia N, Bogaert D, Dowd J, Eckerle I, Goldman LR, Greenhalgh T, Gurdasani D, Hamdy A, Hanage WP, Hodcroft EB, Hyde Z, Kellam P, Kelly-Irving M, Krammer F, Lipsitch M, McNally A, McKee M, Nouri A, Pimenta D, Priesemann V, Rutter H, Silver J, Sridhar D, Swanton C, Walensky RP, Yamey G, Ziauddeen H.Lancet. 2020 Oct 31;396(10260):e71-e72. doi: 10.1016/S0140-6736(20)32153-X. Epub 2020 Oct 15.PMID: 33069277 

Validation and clinical evaluation of a SARS-CoV-2 surrogate virus neutralisation test (sVNT).
Meyer B, Reimerink J, Torriani G, Brouwer F, Godeke GJ, Yerly S, Hoogerwerf M, Vuilleumier N, Kaiser L, Eckerle I, Reusken C.Emerg Microbes Infect. 2020 Dec;9(1):2394-2403. doi: 10.1080/22221751.2020.1835448.PMID: 33043818 

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19).
Baggio S, L'Huillier AG, Yerly S, Bellon M, Wagner N, Rohr M, Huttner A, Blanchard-Rohner G, Loevy N, Kaiser L, Jacquerioz F, Eckerle I.Clin Infect Dis. 2021 Jul 1;73(1):148-150. doi: 10.1093/cid/ciaa1157.PMID: 32761228 

Development and Validation of the Elecsys Anti-SARS-CoV-2 Immunoassay as a Highly Specific Tool for Determining Past Exposure to SARS-CoV-2.
Muench P, Jochum S, Wenderoth V, Ofenloch-Haehnle B, Hombach M, Strobl M, Sadlowski H, Sachse C, Torriani G, Eckerle I, Riedel A.J Clin Microbiol. 2020 Sep 22;58(10):e01694-20. doi: 10.1128/JCM.01694-20. Print 2020 Sep 22.PMID: 32747400 

Head-to-Head Accuracy Comparison of Three Commercial COVID-19 IgM/IgG Serology Rapid Tests.
Andrey DO, Cohen P, Meyer B, Torriani G, Yerly S, Mazza L, Calame A, Arm-Vernez I, Guessous I, Stringhini S, Roux-Lombard P, Fontao L, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N.J Clin Med. 2020 Jul 24;9(8):2369. doi: 10.3390/jcm9082369.PMID: 32722191 

Diagnostic accuracy of Augurix COVID-19 IgG serology rapid test.
Andrey DO, Cohen P, Meyer B, Torriani G, Yerly S, Mazza L, Calame A, Arm-Vernez I, Guessous I, Stringhini S, Roux-Lombard P, Fontao L, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N; Geneva Centre for Emerging Viral Diseases.Eur J Clin Invest. 2020 Oct;50(10):e13357. doi: 10.1111/eci.13357. Epub 2020 Aug 11.PMID: 32691863 

Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland.
Perez-Saez J, Lauer SA, Kaiser L, Regard S, Delaporte E, Guessous I, Stringhini S, Azman AS; Serocov-POP Study Group.Lancet Infect Dis. 2021 Apr;21(4):e69-e70. doi: 10.1016/S1473-3099(20)30584-3. Epub 2020 Jul 14.PMID: 32679085 

SARS-CoV-2 seroprevalence in COVID-19 hotspots.
Eckerle I, Meyer B.Lancet. 2020 Aug 22;396(10250):514-515. doi: 10.1016/S0140-6736(20)31482-3. Epub 2020 Jul 6.PMID: 32645348 

Culture-Competent SARS-CoV-2 in Nasopharynx of Symptomatic Neonates, Children, and Adolescents.
L'Huillier AG, Torriani G, Pigny F, Kaiser L, Eckerle I.Emerg Infect Dis. 2020 Oct;26(10):2494-2497. doi: 10.3201/eid2610.202403. Epub 2020 Jun 30.PMID: 32603290 

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study.
Stringhini S, Wisniak A, Piumatti G, Azman AS, Lauer SA, Baysson H, De Ridder D, Petrovic D, Schrempft S, Marcus K, Yerly S, Arm Vernez I, Keiser O, Hurst S, Posfay-Barbe KM, Trono D, Pittet D, Gétaz L, Chappuis F, Eckerle I, Vuilleumier N, Meyer B, Flahault A, Kaiser L, Guessous I.Lancet. 2020 Aug 1;396(10247):313-319. doi: 10.1016/S0140-6736(20)31304-0. Epub 2020 Jun 11.PMID: 32534626 

Unbiased metagenomic next-generation sequencing of blood from hospitalized febrile children in Gabon.
Fernandes JF, Laubscher F, Held J, Eckerle I, Docquier M, Grobusch MP, Mordmüller B, Kaiser L, Cordey S.Emerg Microbes Infect. 2020 Dec;9(1):1242-1244. doi: 10.1080/22221751.2020.1772015.PMID: 32524907 

Delayed Laboratory Response to COVID-19 Caused by Molecular Diagnostic Contamination.
Mögling R, Meijer A, Berginc N, Bruisten S, Charrel R, Coutard B, Eckerle I, Enouf V, Hungnes O, Korukluoglu G, Kossyvakis T, Mentis A, Molenkamp R, Muradrasoli S, Papa A, Pigny F, Thirion L, van der Werf S, Reusken C.Emerg Infect Dis. 2020 Aug;26(8):1944-1946. doi: 10.3201/eid2608.201843. Epub 2020 May 20.PMID: 32433015 

Orthohantavirus Isolated in Reservoir Host Cells Displays Minimal Genetic Changes and Retains Wild-Type Infection Properties.
Strandin T, Smura T, Ahola P, Aaltonen K, Sironen T, Hepojoki J, Eckerle I, Ulrich RG, Vapalahti O, Kipar A, Forbes KM.Viruses. 2020 Apr 17;12(4):457. doi: 10.3390/v12040457.PMID: 32316667 

COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation.
Salathé M, Althaus CL, Neher R, Stringhini S, Hodcroft E, Fellay J, Zwahlen M, Senti G, Battegay M, Wilder-Smith A, Eckerle I, Egger M, Low N.Swiss Med Wkly. 2020 Mar 19;150:w20225. doi: 10.4414/smw.2020.20225. eCollection 2020 Mar 9.PMID: 32191813

Covid-19: a puzzle with many missing pieces.
Vetter P, Eckerle I, Kaiser L.BMJ. 2020 Feb 19;368:m627. doi: 10.1136/bmj.m627.PMID: 32075791 No abstract available.

Causes of fever in Gabonese children: a cross-sectional hospital-based study.
Fernandes JF, Held J, Dorn M, Lalremruata A, Schaumburg F, Alabi A, Agbanrin MD, Kokou C, Ben Adande A, Esen M, Eibach D, Adegnika AA, Agnandji ST, Lell B, Eckerle I, Henrichfreise B, Hogan B, May J, Kremsner PG, Grobusch MP, Mordmüller B.Sci Rep. 2020 Feb 7;10(1):2080. doi: 10.1038/s41598-020-58204-2.PMID: 32034188 

Nycteria and Polychromophilus parasite infections of bats in Central Gabon.
Rosskopf SP, Held J, Gmeiner M, Mordmüller B, Matsiégui PB, Eckerle I, Weber N, Matuschewski K, Schaer J.Infect Genet Evol. 2019 Mar;68:30-34. doi: 10.1016/j.meegid.2018.11.022. Epub 2018 Nov 30.PMID: 30508688

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.
Slater T, Eckerle I, Chang KC.Virol J. 2018 Apr 10;15(1):68. doi: 10.1186/s12985-018-0979-6.PMID: 29636078 

_______________

Research Groups

The group "Emerging viruses" is led by Pr Isabella Eckerle, member of the "High-level European expert group proposing a roadmap towards stabilization of the COVID-19 pandemic in the European region".

This research group is the affiliated research group of the Geneva Centre for Emerging Viral Diseases, a joint institution between the University Hospitals of Geneva (HUG) and the Faculty of Medicine, University of Geneva, with the main laboratory of research group being located at the Department of Microbiology and Molecular Medicine (MIMOL) at the Centre medical universitaire (CMU).

The focus of our research is the laboratory-based risk assessment of novel and emerging zoonotic viruses by molecular and classical virological methods using innovative and highly specific cell culture models from humans and animal reservoir hosts. Since the beginning of the SARS-CoV-2 pandemic, our laboratory is strongly involved in both in development and validation of diagnostics for SARS-CoV-2, as well as research projects on SARS-CoV-2, for example on viral shedding, virus isolation studies, creation of a SARS-CoV-2 biobank, molecular as well as phenotypic characterisation and coinfection with other respiratory viruses in primary airway epithelial cells and clinical as well as immunological studies.

The research group is closely connected to the diagnostic virology laboratory and the the Swiss National reference laboratory for emerging viral infections (Centre référence infections virales émergentes, CRIVE) at the HUG. The Centre hosts the only P3 and P4D facilities in the Canton of Geneva, located at the HUG, where our work with infectious SARS-CoV-2 is performed.

Link to the website of Isabella Eckerle's group at the Faculty of Medicine https://www.unige.ch/medecine/demed/en/groupes-de-recherche/isabella-eckerle/ 

The laboratory is one of 26 international reference laboratories for COVID19 testing designated by the World Health Organization, to which our group is contributing in terms of SARS-CoV-2 diagnostic validations (WHO COVID-19 Reference Laboratory Network)
https://www.who.int/docs/default-source/coronaviruse/who-reference-laboratories-providing-confirmatory-testing-for-covid-19.pdf?sfvrsn=a03a01e6_2

The laboratory is also collaborating partner of the Foundation of Innovative Diagnostics (FIND) to provide support for accurate SARS-CoV-2 diagnostics. Updates of current validations for molecular assays and Antigen-detecting rapide diagnostic tests can be found here: https://www.finddx.org/covid-19/sarscov2-eval/

Close collaborations exist also with the Infectious Diseases Service, the Population Epidemiology Unit, the Pediatric Infectious Diseases Unit of the HUG and the Centre of Vaccinology of the Department of Pathology and Immunology at Unige.

Research funds:

Horizon 2020, European Union, Project: “European Clinical Research Alliance on Infectious Diseases – ECRAID-Base

Swiss National Foundation (SNF) National Research Program (NRP) 78 "Covid-19" “Large-scale serological profiling of SARS-CoV-2 and related human CoVs with high-throughput microfluidic nano-immunoassays”, Co-application with Sebastian Maerkl, École polytechnique fédérale de Lausanne (EPFL)

Swiss National Foundation (SNF), Special call on coronaviruses, Project: “Phenotypic characterization of a SARS-CoV-2 clinical strain biobank and risk assessment of evolving virus variants,

Swiss National Foundation (SNF), Special call on coronaviruses Project: “Real-time pandemic functional characterization of SARS-CoV-2”. Co-application with Volker Thiel and Ronald Dijkman (Institute of Virology and Immunologie, Bern). Collaborating laboratory for the Foundation for Innovative Diagnostics (FIND): “Support for accurate 2019-nCoV diagnostics”

Fondation privée HUG: Rapid response support for SARS-CoV-2

Fondation Pictet, Project: “COVID-19, le nouveau défi du Centre de maladies virales émergentes - Understanding transmission & risk factors for COVID-19 in primary cell culture models”

Fondation Ernst et Lucie Schmidheiny, Project: „Assessment of host-switching capacity of newly identified bat filoviruses through single amino acid change in the spike glycoprotein“

Isabella Eckerle is also part of the following initiatives

Ad-hoc commission on SARS-CoV-2 of the Society of Virology (German-speaking virologists, Germany, Switzerland, Austria, “Gesellschaft für Virologie”): https://www.g-f-v.org/stellungnahmen  

The Lancet COVID-19 Commission: Taskforce on the Origins, Early Control of the Pandemic, and One Health Solutions to Future Pandemic Threats: https://covid19commission.org/origins-of-the-pandemic

Co-Author and Co-Initiator of John Snow Memorandum
Alwan NA, Burgess RA, Ashworth S, Beale R, Bhadelia N, Bogaert D, Dowd J, Eckerle I, Goldman LR, Greenhalgh T, Gurdasani D, Hamdy A, Hanage WP, Hodcroft EB, Hyde Z, Kellam P, Kelly-Irving M, Krammer F, Lipsitch M, McNally A, McKee M, Nouri A, Pimenta D, Priesemann V, Rutter H, Silver J, Sridhar D, Swanton C, Walensky RP, Yamey G, Ziauddeen H. Scientific consensus on the COVID-19 pandemic: we need to act now. Lancet. 2020 Oct 15

Invited expert at the World Health Organization, Global research and innovation forum: towards a research roadmap for the 2019 novel Coronavirus, R&D Blueprint Initiative (11-12 February 2020) Part of the expert group on virus’ natural history and transmission

World Health Organization, Target Product Profile Group: COVID-19 Target product profiles for priority diagnostics to support response to the COVID-19 pandemic v.1.0, 29 September 2020, https://www.who.int/publications/m/item/covid-19-target-product-profiles-for-priority-diagnostics-to-support-response-to-the-covid-19-pandemic-v.0.1

World Health Organization: Temporary Advisor to the WHO for the Expert Consultation on mother-to-child transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (Oktober 2020)

Publication list of the group (2018-now)

Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland.
Chen C, Nadeau SA, Topolsky I, Manceau M, Huisman JS, Jablonski KP, Fuhrmann L, Dreifuss D, Jahn K, Beckmann C, Redondo M, Noppen C, Risch L, Risch M, Wohlwend N, Kas S, Bodmer T, Roloff T, Stange M, Egli A, Eckerle I, Kaiser L, Denes R, Feldkamp M, Nissen I, Santacroce N, Burcklen E, Aquino C, de Gouvea AC, Moccia MD, Grüter S, Sykes T, Opitz L, White G, Neff L, Popovic D, Patrignani A, Tracy J, Schlapbach R, Dermitzakis ET, Harshman K, Xenarios I, Pegeot H, Cerutti L, Penet D, Blin A, Elies M, Althaus CL, Beisel C, Beerenwinkel N, Ackermann M, Stadler T.Epidemics. 2021 Aug 9;37:100480. doi: 10.1016/j.epidem.2021.100480. Online ahead of print.PMID: 34488035

Estimating clinical SARS-CoV-2 infectiousness in Vero E6 and primary airway epithelial cells.
Essaidi-Laziosi M, Perez Rodriguez FJ, Hulo N, Jacquerioz F, Kaiser L, Eckerle I. Lancet Microbe. 2021 Aug 27. doi: 10.1016/S2666-5247(21)00216-0. Online ahead of print.PMID: 34485956  

Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains.
Binder F, Gallo G, Bendl E, Eckerle I, Ermonval M, Luttermann C, Ulrich RG.Arch Virol. 2021 Aug 13:1-14. doi: 10.1007/s00705-021-05159-y. Online ahead of print.PMID: 34389893 

SARS-CoV-2 infection as a trigger of humoral response against apolipoprotein A-1.
Pagano S, Yerly S, Meyer B, Juillard C, Suh N, Le Terrier C, Daguer JP, Farrera-Soler L, Barluenga S, Piumatti G, Hartley O, Lemaitre B, Eberhardt CS, Siegrist CA, Eckerle I, Stringhini S, Guessous I, Kaiser L, Pugin J, Winssinger N, Vuilleumier N.Eur J Clin Invest. 2021 Jul 29:e13661. doi: 10.1111/eci.13661. Online ahead of print.PMID: 34324704

Persistence of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance.
Perez-Saez J, Zaballa ME, Yerly S, Andrey DO, Meyer B, Eckerle I, Balavoine JF, Chappuis F, Pittet D, Trono D, Kherad O, Vuilleumier N, Kaiser L, Guessous I, Stringhini S, Azman AS; Specchio-COVID19 Study Group.Clin Microbiol Infect. 2021 Jul 7:S1198-743X(21)00371-2. doi: 10.1016/j.cmi.2021.06.040. Online ahead of print.PMID: 34245905 

SARS-CoV-2 rapid diagnostic tests for emerging variants.
Bekliz M, Adea K, Essaidi-Laziosi M, Sacks JA, Escadafal C, Kaiser L, Eckerle I.Lancet Microbe. 2021 Aug;2(8):e351. doi: 10.1016/S2666-5247(21)00147-6. Epub 2021 Jun 29.PMID: 34223400 

Diagnostic Accuracy of SARS-CoV-2 Rapid Antigen Detection Testing in Symptomatic and Asymptomatic Children in the Clinical Setting.
L'Huillier AG, Lacour M, Sadiku D, Gadiri MA, De Siebenthal L, Schibler M, Eckerle I, Pinösch S, Kaiser L, Gervaix A, Glangetas A, Galetto-Lacour A, Lacroix L.J Clin Microbiol. 2021 Aug 18;59(9):e0099121. doi: 10.1128/JCM.00991-21. Epub 2021 Aug 18.PMID: 34190574 

Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2.
Ngo Nsoga MT, Kronig I, Perez Rodriguez FJ, Sattonnet-Roche P, Da Silva D, Helbling J, Sacks JA, de Vos M, Boehm E, Gayet-Ageron A, Berger A, Jacquerioz-Bausch F, Chappuis F, Kaiser L, Schibler M, Renzoni A, Eckerle I.PLoS One. 2021 Jun 24;16(6):e0253321. doi: 10.1371/journal.pone.0253321. eCollection 2021.PMID: 34166410 

Sero-molecular epidemiology of hepatitis E virus in pigs and human contacts in Ghana.
Yeboah R, Sylverken AA, Owusu M, El-Duah P, Burimuah V, Frimpong Y, Lamptey J, Eckerle I, Meyer B, Antwi C, Agbenyaga O, Folitse R, Emikpe B, Oppong SK, Adu-Sarkodie Y, Drosten C.One Health Outlook. 2021 Jun 22;3(1):13. doi: 10.1186/s42522-021-00043-w.PMID: 34154674 

Insights into household transmission of SARS-CoV-2 from a population-based serological survey.
Bi Q, Lessler J, Eckerle I, Lauer SA, Kaiser L, Vuilleumier N, Cummings DAT, Flahault A, Petrovic D, Guessous I, Stringhini S, Azman AS; SEROCoV-POP Study Group.Nat Commun. 2021 Jun 15;12(1):3643. doi: 10.1038/s41467-021-23733-5.PMID: 34131124 

Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland.
Stringhini S, Zaballa ME, Pullen N, de Mestral C, Perez-Saez J, Dumont R, Picazio A, Pennacchio F, Dibner Y, Yerly S, Baysson H, Vuilleumier N, Balavoine JF, Bachmann D, Trono D, Pittet D, Chappuis F, Kherad O, Kaiser L, Azman AS; SEROCoV-WORK + Study Group, Guessous I.Nat Commun. 2021 Jun 8;12(1):3455. doi: 10.1038/s41467-021-23796-4.PMID: 34103517 

Novel SARS-CoV-2 variants: the pandemics within the pandemic.
Boehm E, Kronig I, Neher RA, Eckerle I, Vetter P, Kaiser L; Geneva Centre for Emerging Viral Diseases.Clin Microbiol Infect. 2021 Aug;27(8):1109-1117. doi: 10.1016/j.cmi.2021.05.022. Epub 2021 May 17.PMID: 34015535 

Case Report: Stepwise Anti-Inflammatory and Anti-SARS-CoV-2 Effects Following Convalescent Plasma Therapy With Full Clinical Recovery.
Zimmerli A, Monti M, Fenwick C, Eckerle I, Beigelman-Aubry C, Pellaton C, Jaton K, Dumas D, Stamm GM, Infanti L, Andreu-Ullrich H, Germann D, Mean M, Vollenweider P, Stadelmann R, Prella M, Comte D, Guery B, Gachoud D, Rufer N.Front Immunol. 2021 Apr 21;12:613502. doi: 10.3389/fimmu.2021.613502. eCollection 2021.PMID: 33968017 

SARS-CoV-2 viral load kinetics in symptomatic children, adolescents and adults.
Bellon M, Baggio S, Bausch FJ, Spechbach H, Salamun J, Genecand C, Tardin A, Kaiser L, L'Huillier AG, Eckerle I.Clin Infect Dis. 2021 May 5:ciab396. doi: 10.1093/cid/ciab396. Online ahead of print.PMID: 33949655 

A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples.
Swank Z, Michielin G, Yip HM, Cohen P, Andrey DO, Vuilleumier N, Kaiser L, Eckerle I, Meyer B, Maerkl SJ.Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2025289118. doi: 10.1073/pnas.2025289118.PMID: 33945500 

Head-to-Head Evaluation of Five Automated SARS-CoV-2 Serology Immunoassays in Various Prevalence Settings.
Andrey DO, Yerly S, Meyer B, Arm-Vernez I, Roux-Lombard P, Togni G, Guessous I, Spechbach H, Stringhini S, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N.J Clin Med. 2021 Apr 10;10(8):1605. doi: 10.3390/jcm10081605.PMID: 33920076 

SARS-CoV-2 N501Y Introductions and Transmissions in Switzerland from Beginning of October 2020 to February 2021-Implementation of Swiss-Wide Diagnostic Screening and Whole Genome Sequencing.
Goncalves Cabecinhas AR, Roloff T, Stange M, Bertelli C, Huber M, Ramette A, Chen C, Nadeau S, Gerth Y, Yerly S, Opota O, Pillonel T, Schuster T, Metzger CMJA, Sieber J, Bel M, Wohlwend N, Baumann C, Koch MC, Bittel P, Leuzinger K, Brunner M, Suter-Riniker F, Berlinger L, Søgaard KK, Beckmann C, Noppen C, Redondo M, Steffen I, Seth-Smith HMB, Mari A, Lienhard R, Risch M, Nolte O, Eckerle I, Martinetti Lucchini G, Hodcroft EB, Neher RA, Stadler T, Hirsch HH, Leib SL, Risch L, Kaiser L, Trkola A, Greub G, Egli A.Microorganisms. 2021 Mar 25;9(4):677. doi: 10.3390/microorganisms9040677.PMID: 33806013 

Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers.
Berger A, Nsoga MTN, Perez-Rodriguez FJ, Aad YA, Sattonnet-Roche P, Gayet-Ageron A, Jaksic C, Torriani G, Boehm E, Kronig I, Sacks JA, de Vos M, Bausch FJ, Chappuis F, Renzoni A, Kaiser L, Schibler M, Eckerle I.PLoS One. 2021 Mar 31;16(3):e0248921. doi: 10.1371/journal.pone.0248921. eCollection 2021.PMID: 33788882 

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroconversion and occupational exposure of employees at a Swiss university hospital: A large longitudinal cohort study.
Martischang R, Iten A, Arm I, Abbas M, Meyer B, Yerly S, Eckerle I, Pralong J, Sauser J, Suard JC, Kaiser L, Pittet D, Harbarth S.Infect Control Hosp Epidemiol. 2021 Mar 19:1-8. doi: 10.1017/ice.2021.117. Online ahead of print.PMID: 33736734 

Molecular epidemiology of respiratory syncytial virus in children in sub-Saharan Africa.
Ihling CM, Schnitzler P, Heinrich N, Mangu C, Sudi L, Souares A, Gies S, Sié A, Coulibaly B, Ouédraogo AT, Mordmüller B, Held J, Adegnika AA, Fernandes JF, Eckerle I, May J, Hogan B, Eibach D, Tabatabai J.Trop Med Int Health. 2021 Jul;26(7):810-822. doi: 10.1111/tmi.13573. Epub 2021 Mar 28.PMID: 33683751

Clinical, virologic and immunologic features of a mild case of SARS-CoV-2 reinfection.
Vetter P, Cordey S, Schibler M, Vieux L, Despres L, Laubscher F, Andrey DO, Martischang R, Harbarth S, Cuvelier C, Bekliz M, Eckerle I, Siegrist CA, Didierlaurent AM, Eberhardt CS, Meyer B, Kaiser L; Geneva Center for Emerging Viral Diseases.Clin Microbiol Infect. 2021 Feb 20;27(5):791.e1-4. doi: 10.1016/j.cmi.2021.02.010. Online ahead of print.PMID: 33618012 

Viral Loads of SARS-CoV-2 in Young Children.
L'Huillier AG, Baggio S, Eckerle I.JAMA Pediatr. 2021 May 1;175(5):529-530. doi: 10.1001/jamapediatrics.2020.5548.PMID: 33523127 

Viral co-infections among SARS-CoV-2-infected children and infected adult household contacts.
Pigny F, Wagner N, Rohr M, Mamin A, Cherpillod P, Posfay-Barbe KM, Kaiser L, Eckerle I, L'Huillier AG; Geneva Pediatric COVID Group.Eur J Pediatr. 2021 Jun;180(6):1991-1995. doi: 10.1007/s00431-021-03947-x. Epub 2021 Jan 27.PMID: 33502627 

Puumala Virus Infection in Family, Switzerland.
Vetter P, L'Huillier AG, Montalbano MF, Pigny F, Eckerle I, Torriani G, Rothenberger S, Laubscher F, Cordey S, Kaiser L, Schibler M.Emerg Infect Dis. 2021 Feb;27(2):658-660. doi: 10.3201/eid2702.203770.PMID: 33496646 

An action plan for pan-European defence against new SARS-CoV-2 variants.
Priesemann V, Balling R, Brinkmann MM, Ciesek S, Czypionka T, Eckerle I, Giordano G, Hanson C, Hel Z, Hotulainen P, Klimek P, Nassehi A, Peichl A, Perc M, Petelos E, Prainsack B, Szczurek E.Lancet. 2021 Feb 6;397(10273):469-470. doi: 10.1016/S0140-6736(21)00150-1. Epub 2021 Jan 21.PMID: 33485462 

Antibody persistence in the first 6 months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study.
L'Huillier AG, Meyer B, Andrey DO, Arm-Vernez I, Baggio S, Didierlaurent A, Eberhardt CS, Eckerle I, Grasset-Salomon C, Huttner A, Posfay-Barbe KM, Royo IS, Pralong JA, Vuilleumier N, Yerly S, Siegrist CA, Kaiser L; Geneva Centre for Emerging Viral Diseases.Clin Microbiol Infect. 2021 Jan 20;27(5):784.e1-8. doi: 10.1016/j.cmi.2021.01.005. Online ahead of print.PMID: 33482352 

Precision global health for real-time action.
Flahault A, Utzinger J, Eckerle I, Sheath DJ, de Castañeda RR, Bolon I, Bempong NE, Andayi F.Lancet Digit Health. 2020 Feb;2(2):e58-e59. doi: 10.1016/S2589-7500(19)30240-7. Epub 2020 Jan 27.PMID: 33334561 Review. 

Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity.
Yahav D, Yelin D, Eckerle I, Eberhardt CS, Wang J, Cao B, Kaiser L.Clin Microbiol Infect. 2021 Mar;27(3):315-318. doi: 10.1016/j.cmi.2020.11.028. Epub 2020 Dec 5.PMID: 33285276 

Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019.
Grazioli S, Tavaglione F, Torriani G, Wagner N, Rohr M, L'Huillier AG, Leclercq C, Perrin A, Bordessoule A, Beghetti M, Schmid JP, Vavassori S, Perreau M, Eberhardt C, Didierlaurent A, Kaiser L, Eckerle I, Roux-Lombard P, Blanchard-Rohner G.J Pediatric Infect Dis Soc. 2021 Aug 14;10(6):706-713. doi: 10.1093/jpids/piaa142.PMID: 33180935 

Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series.
Vetter P, Eberhardt CS, Meyer B, Martinez Murillo PA, Torriani G, Pigny F, Lemeille S, Cordey S, Laubscher F, Vu DL, Calame A, Schibler M, Jacquerioz F, Blanchard-Rohner G, Siegrist CA, Kaiser L, Didierlaurent AM, Eckerle I.mSphere. 2020 Nov 11;5(6):e00827-20. doi: 10.1128/mSphere.00827-20.PMID: 33177214 

Scientific consensus on the COVID-19 pandemic: we need to act now.
Alwan NA, Burgess RA, Ashworth S, Beale R, Bhadelia N, Bogaert D, Dowd J, Eckerle I, Goldman LR, Greenhalgh T, Gurdasani D, Hamdy A, Hanage WP, Hodcroft EB, Hyde Z, Kellam P, Kelly-Irving M, Krammer F, Lipsitch M, McNally A, McKee M, Nouri A, Pimenta D, Priesemann V, Rutter H, Silver J, Sridhar D, Swanton C, Walensky RP, Yamey G, Ziauddeen H.Lancet. 2020 Oct 31;396(10260):e71-e72. doi: 10.1016/S0140-6736(20)32153-X. Epub 2020 Oct 15.PMID: 33069277 

Validation and clinical evaluation of a SARS-CoV-2 surrogate virus neutralisation test (sVNT).
Meyer B, Reimerink J, Torriani G, Brouwer F, Godeke GJ, Yerly S, Hoogerwerf M, Vuilleumier N, Kaiser L, Eckerle I, Reusken C.Emerg Microbes Infect. 2020 Dec;9(1):2394-2403. doi: 10.1080/22221751.2020.1835448.PMID: 33043818 

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19).
Baggio S, L'Huillier AG, Yerly S, Bellon M, Wagner N, Rohr M, Huttner A, Blanchard-Rohner G, Loevy N, Kaiser L, Jacquerioz F, Eckerle I.Clin Infect Dis. 2021 Jul 1;73(1):148-150. doi: 10.1093/cid/ciaa1157.PMID: 32761228 

Development and Validation of the Elecsys Anti-SARS-CoV-2 Immunoassay as a Highly Specific Tool for Determining Past Exposure to SARS-CoV-2.
Muench P, Jochum S, Wenderoth V, Ofenloch-Haehnle B, Hombach M, Strobl M, Sadlowski H, Sachse C, Torriani G, Eckerle I, Riedel A.J Clin Microbiol. 2020 Sep 22;58(10):e01694-20. doi: 10.1128/JCM.01694-20. Print 2020 Sep 22.PMID: 32747400 

Head-to-Head Accuracy Comparison of Three Commercial COVID-19 IgM/IgG Serology Rapid Tests.
Andrey DO, Cohen P, Meyer B, Torriani G, Yerly S, Mazza L, Calame A, Arm-Vernez I, Guessous I, Stringhini S, Roux-Lombard P, Fontao L, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N.J Clin Med. 2020 Jul 24;9(8):2369. doi: 10.3390/jcm9082369.PMID: 32722191 

Diagnostic accuracy of Augurix COVID-19 IgG serology rapid test.
Andrey DO, Cohen P, Meyer B, Torriani G, Yerly S, Mazza L, Calame A, Arm-Vernez I, Guessous I, Stringhini S, Roux-Lombard P, Fontao L, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N; Geneva Centre for Emerging Viral Diseases.Eur J Clin Invest. 2020 Oct;50(10):e13357. doi: 10.1111/eci.13357. Epub 2020 Aug 11.PMID: 32691863 

Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland.
Perez-Saez J, Lauer SA, Kaiser L, Regard S, Delaporte E, Guessous I, Stringhini S, Azman AS; Serocov-POP Study Group.Lancet Infect Dis. 2021 Apr;21(4):e69-e70. doi: 10.1016/S1473-3099(20)30584-3. Epub 2020 Jul 14.PMID: 32679085 

SARS-CoV-2 seroprevalence in COVID-19 hotspots.
Eckerle I, Meyer B.Lancet. 2020 Aug 22;396(10250):514-515. doi: 10.1016/S0140-6736(20)31482-3. Epub 2020 Jul 6.PMID: 32645348 

Culture-Competent SARS-CoV-2 in Nasopharynx of Symptomatic Neonates, Children, and Adolescents.
L'Huillier AG, Torriani G, Pigny F, Kaiser L, Eckerle I.Emerg Infect Dis. 2020 Oct;26(10):2494-2497. doi: 10.3201/eid2610.202403. Epub 2020 Jun 30.PMID: 32603290 

Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study.
Stringhini S, Wisniak A, Piumatti G, Azman AS, Lauer SA, Baysson H, De Ridder D, Petrovic D, Schrempft S, Marcus K, Yerly S, Arm Vernez I, Keiser O, Hurst S, Posfay-Barbe KM, Trono D, Pittet D, Gétaz L, Chappuis F, Eckerle I, Vuilleumier N, Meyer B, Flahault A, Kaiser L, Guessous I.Lancet. 2020 Aug 1;396(10247):313-319. doi: 10.1016/S0140-6736(20)31304-0. Epub 2020 Jun 11.PMID: 32534626 

Unbiased metagenomic next-generation sequencing of blood from hospitalized febrile children in Gabon.
Fernandes JF, Laubscher F, Held J, Eckerle I, Docquier M, Grobusch MP, Mordmüller B, Kaiser L, Cordey S.Emerg Microbes Infect. 2020 Dec;9(1):1242-1244. doi: 10.1080/22221751.2020.1772015.PMID: 32524907 

Delayed Laboratory Response to COVID-19 Caused by Molecular Diagnostic Contamination.
Mögling R, Meijer A, Berginc N, Bruisten S, Charrel R, Coutard B, Eckerle I, Enouf V, Hungnes O, Korukluoglu G, Kossyvakis T, Mentis A, Molenkamp R, Muradrasoli S, Papa A, Pigny F, Thirion L, van der Werf S, Reusken C.Emerg Infect Dis. 2020 Aug;26(8):1944-1946. doi: 10.3201/eid2608.201843. Epub 2020 May 20.PMID: 32433015 

Orthohantavirus Isolated in Reservoir Host Cells Displays Minimal Genetic Changes and Retains Wild-Type Infection Properties.
Strandin T, Smura T, Ahola P, Aaltonen K, Sironen T, Hepojoki J, Eckerle I, Ulrich RG, Vapalahti O, Kipar A, Forbes KM.Viruses. 2020 Apr 17;12(4):457. doi: 10.3390/v12040457.PMID: 32316667 

COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation.
Salathé M, Althaus CL, Neher R, Stringhini S, Hodcroft E, Fellay J, Zwahlen M, Senti G, Battegay M, Wilder-Smith A, Eckerle I, Egger M, Low N.Swiss Med Wkly. 2020 Mar 19;150:w20225. doi: 10.4414/smw.2020.20225. eCollection 2020 Mar 9.PMID: 32191813

Covid-19: a puzzle with many missing pieces.
Vetter P, Eckerle I, Kaiser L.BMJ. 2020 Feb 19;368:m627. doi: 10.1136/bmj.m627.PMID: 32075791 No abstract available.

Causes of fever in Gabonese children: a cross-sectional hospital-based study.
Fernandes JF, Held J, Dorn M, Lalremruata A, Schaumburg F, Alabi A, Agbanrin MD, Kokou C, Ben Adande A, Esen M, Eibach D, Adegnika AA, Agnandji ST, Lell B, Eckerle I, Henrichfreise B, Hogan B, May J, Kremsner PG, Grobusch MP, Mordmüller B.Sci Rep. 2020 Feb 7;10(1):2080. doi: 10.1038/s41598-020-58204-2.PMID: 32034188 

Nycteria and Polychromophilus parasite infections of bats in Central Gabon.
Rosskopf SP, Held J, Gmeiner M, Mordmüller B, Matsiégui PB, Eckerle I, Weber N, Matuschewski K, Schaer J.Infect Genet Evol. 2019 Mar;68:30-34. doi: 10.1016/j.meegid.2018.11.022. Epub 2018 Nov 30.PMID: 30508688

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.
Slater T, Eckerle I, Chang KC.Virol J. 2018 Apr 10;15(1):68. doi: 10.1186/s12985-018-0979-6.PMID: 29636078 

Dernière mise à jour : 08/10/2021